Two pharmaceutical giants- Eisai & Purdue- are revealing their latest findings in insomnia clinical trials at the 32nd Annual Meeting of the Associated Professional Sleep Societies (SLEEP 2018). Findings include results from insomnia trials performed here at NeuroTrials Research.
Of note, Eisai and Purdue Pharma will present data on a Phase I safety study that assessed the ability to awaken to an auditory stimulus and maintain balance (a predictor of risk for falls) and perform on tests of memory and attention in the middle of the night and the next morning. The study demonstrated that balance was statistically significantly worse for zolpidem ER 6.25 mg compared with both lemborexant 5 mg and 10 mg in healthy volunteers age 55 and older, and the primary endpoint
was achieved. In this study, headache was the only adverse event (AE) observed in two or more people taking lemborexant.
Another Phase I study, which evaluated next-morning effects via an on-road driving test, also achieved its primary objective, demonstrating no significant difference in next-morning driving performance versus placebo. This study was conducted versus placebo, with zopiclone included as a positive control, to evaluate potential next-morning impairment by measuring healthy adult and elderly participants’ driving performance. In this study, the most common AEs observed in the lemborexant were drowsiness, headache, and dry mouth.
“It is important that a treatment for sleep/wake regulation allows a patient to not only sleep well, but also wake well. Sleeping well includes the ability to fall asleep and stay asleep through the night, and waking well includes the ability to wake in the middle of the night, if needed, or the next day without impairment,” said Russell Rosenberg, PhD, D.ABSM, NeuroTrials CEO, principal investigator, and former Chairman of the Board of the National Sleep Foundation. “These studies provide important information about how lemborexant affects the ability to awaken after sleep.”
Thank you to all our volunteers who participated! We are moving insomnia research forward.
Are you ready to spring forward?
NeuroTrials founder & CEO Dr. Russell Rosenberg recently sat down with Fox5 to offer tips & tricks to keep you on track when we move our clocks up by an hour tonight.
Sunday morning, and for the rest of the week, get up and get outdoors, and into the sunlight, which will nudge your brain to wake up. Rosenberg says short, daytime naps can help, too.
Read the full article here.
NeuroTrials research participant Joe Kim & medical director Dr. Michael Lacey were recently featured in a Fox5 piece on shift work sleep disorder.
It's a problem for people who work overnights, rotating and early morning shifts.
For more information on this study, visit our study page.
"For many people, one medication does not fit all."
NeuroTrials Research CEO Dr. Russell Rosenberg recently sat down with Keisha Lancelin of Focus Atlanta to discuss treatment-resistant depression & our latest research study for major depressive disorder. Watch the full interview below.
For more information about this study, visit our study landing page.
September 21 is World Alzheimer's Day. Here at NeuroTrials Research, we continue to do our part to further research & seek out cures for Alzheimer's as well as end side effects associated with certain Alzheimer's medication. We are so thankful to our research participants, past and present, who have furthered the medical community's understanding of Alzheimer's disease.
To read about past participants & studies, view our previous media coverage including an AJC article & WSB interview.
For more information on current Alzheimer's studies, visit our studies page.
Are you keeping your brain healthy? 5 simple tips from ADI:
Gunther Eichler, 73, can't fall asleep at night and fights to stay awake during the day.
"I can be sitting here talking to you, and my eyes will close and I can fall asleep," Eichler told 11Alive's Jennifer Leslie.
The Alpharetta resident was diagnosed with Parkinson's disease 14 years ago but just recently began struggling with sleep.
NeuroTrials Research is the only facility in Georgia and only one of 15 nationwide investigating the link between Parkinson’s disease and excessive sleepiness.
Dr. Lacey & Mr. Eichler sat down with Jennifer Leslie at 11Alive to share their stories & information on our latest Parkinson's research.
Read the full article.
More information about the study.
If you’ll be hitting roadways this weekend, NeuroTrials wants to make sure you get enough sleep. As our own Dr. Rosenberg explained to the AJC in an article earlier this year, drowsy driving is comparable to driving drunk. While drunk and distracted driving, like texting, get lots of attention, a sleep deficit can be just as dangerous and it’s something we can easily control, Dr. Rosenberg says. Wishing our family and friends good sleep and safe driving this holiday!
April 23-29, 2017 is the National Sleep Foundation's annual Sleep Awareness Week!
This year, the NSF is exploring the theme “Sleep Better. Feel Better” to inspire Americans to consider how sleep effects their daily lives, and reinforce the many benefits associated with making healthy sleep habits a priority. A good night’s sleep improves not just health, but mood, productivity, well-being, and overall quality of life.
At the end of the week, the NSF will release results from its annual survey of Americans about their overall sleep quality. One figure we already know is that 25% of all Americans have trouble sleeping. If you are among that 25%, you may qualify for a new research study here at NeuroTrials.
Learn more at the study landing page.
“Instead of focusing on the cure, in this unique proof of concept study, we’re trying to better patient’s lifestyle. They can stay on their current medication if they’re stable and that’s a very comforting situation for them.”
Gunther Eichler, 73, from Alpharetta, similarly experiences excessive sleepiness during the day. He’s been living with Parkinson’s since 2003 when shaking in his left hand was the first indication of the disease’s onset. In fact, before he was diagnosed with the disease, he once fell asleep at the wheel and “it almost killed me,” he said.
“I hit a road sign which made such a loud noise that it woke me up. I was headed straight for a bridge and I woke me up just in time,” Eichler, a veteran, said. He no longer drives.
To read the full press release, including interviews with another PD patient, click here.
Have your sleep habits changed with your Parkinson's disease?
You may qualify for this study if you:
For more information call 404-851-9934 or visit the study page.